Founder of Telomere DNA and Ribosomal DNA Co-regulation Model for Cell Senescence (TRCS)
Founder and Chief Scientific Officer of Fuzhuang Therapeutics
Pioneering Researcher in Cellular Senescence and Rejuvenation Biotechnology
"My research indicates that aging is essentially a genetic program driven by telomeres and rDNA through the P53 pathway, rather than the accumulation of damage. From the perspective of first principles, the lifespan of a species is determined by the shortening rate of telomeres and rDNA arrays."Explore Bilu's 30-Year Journey
"In this interview, I explain how the TRCS model provides a unified framework for understanding aging as a genetic program driven by telomeres and rDNA through the P53 pathway rather than damage accumulation. This represents a paradigm shift in how we approach age-related diseases, longevity and rejuvenation."Watch Full Interview
After more than 30 years of intensive research, analyzing numerous theories of aging and anti-aging methods, Huang Bilu pointed out the shortcomings of existing theories and innovatively proposed the “Telomere DNA and Ribosomal DNA Co-regulation Model (TRCS).” This model indicates that cellular aging and the Hayflick limit are co-regulated by telomeres and rDNA through P53 pathway, which has been experimentally verified to be correct.
Read the TRCS Paper
Based on the TRCS model proposed by Bilu Huang, the most ideal solution has been provided for curing Alzheimer's disease, cardiovascular and cerebrovascular diseases, tumors and other age-related diseases and significantly extending lifespan.
Explore Fuzhuang TherapeuticsSSRN Electronic Journal, 2025
View PublicationSSRN Electronic Journal, 2025
View PublicationSSRN Electronic Journal, 2025
View PublicationSSRN Electronic Journal, 2025
View PublicationSSRN Electronic Journal, 2025
View PublicationSSRN Electronic Journal, 2025
View PublicationSSRN Electronic Journal, 2025
View PublicationNegative, 2021
View PublicationYanjing Medical Correspondence, 1998
View PublicationThe TRCS model provides a basic framework for the development of therapeutics for age-related diseases and has the potential to completely cure cancers, neurodegenerative diseases, and metabolic syndromes.
Huang's research provides a unified direction for reversing aging, treating degenerative diseases, and significantly extending lifespan. It is based on curing age-related diseases and significantly prolonging life from the underlying mechanisms of aging, rather than simply providing symptomatic treatment for each age-related disease.
By addressing the fundamental processes of aging, this research has the potential to alleviate the global burden of age-related diseases, with significant implications for healthcare systems worldwide.
We welcome partnerships with academic institutions, research organizations, and industry leaders to conduct academic validation and develop innovative therapies for age-related degenerative diseases.